Randomized Trial of Endoscopic or Open Vein- Graft Harvesting for Coronary-Artery Bypass the Randomized Endovein Graft Prospective (REGROUP) trial NEJM Abstract ◯背景 ・大伏在静脈グラフとはCABGでもっともよく使用される ・静脈グラフとの採取…

Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury The POLAR Randomized Clinical Trial JAMA Abstract ◯重要 ・重症頭部外傷後に、予防的低体温の導入は神経保護的で長期神…

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness NEJM Abstract ◯背景 ・ICUのせん妄患者に対する抗精神病薬の効果に対してはconflicting data ◯方法 ・randomized, double-blind, placebo-controlled trial ・急性呼吸不全 or …

Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery NEJM Abstract ◯背景 ・以前にmoderate-high risk for deathがある心臓手術を受ける患者に対してrestrictive transfusion strategyはliberal strategyに対して以下の項目…

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome ODYSSEY OUTCOMES trial NEJM Abstract ◯背景 ・ACS患者は虚血性心血管イベントの再発の高リスクである ・alirocumab, a human monoclonal antibody to proprotein convertase subtil…

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury A Randomized Clinical Trial STOP-AKI trial JAMA Abstract ◯重要 ・Sepsis-associated acute kidney injury (A…

Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients A Randomized Clinical Trial JAMA Abstract ◯重要 ・抗菌薬耐性のmoderate-high levelsのICU患者のoutcomesについてchlorhexidin…

Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure The Breathe Randomized Clinical Trial JAMA Abstra…

Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure The HIGH Randomized Clinical Trial JAMA Abstract ◯重要 ・急性低酸素性呼吸不全(AHRF)に対してhigh-flow nasal…